High Performance Liquid Chromatography (HPLC) Market Snapshot
“The High Performance Liquid Chromatography (HPLC) Market is estimated to increase at a CAGR of 5.34% from $ 4.77 Billion in 2023 to $ 7.50 billion by 2030.”
High Performance Liquid Chromatography (HPLC) is the primary analytical method used in laboratories worldwide for separating, recognizing, and quantifying mixture components.
How Does High Performance Liquid Chromatography (HPLC) Work?
Column chromatography involves a solvent flowing through a column filled with an adsorbent-filled material, typically a granular substance like silica or polymers, under intense pressures of up to 400 atmospheres. HPLC has significantly improved this process, allowing for more accurate and efficient analysis.
Column chromatography is faster due to pressure, allowing for smaller particles in the column packing material. This allows for better separation of mixture components. The stationary phase interacts with molecules over a larger surface area in smaller particles, while the mobile phase, typically a combination of solvents like water, acetonitrile, and/or methanol, is pressurized.
The interaction between mixture components and absorbent particles determines their distance, resulting in varying elution rates and component separation. HPLC is highly sensitive and automated, unlike column chromatography, which is influenced by the interaction between components.
Every High Performance Liquid Chromatography (HPLC) analysis includes the following steps:
- Mobile phase begins to flow.
- Sample injection
- Compound separation
- Analyte detection
- Chromatogram generation.
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Factors affecting High Performance Liquid Chromatography (HPLC) separations
HPLC separations are influenced by temperature, stationary phase chemistry, and mobile phase composition. The right stationary phase is crucial for successful separation, as analytes have different affinity for the stationary phase. Primary variables affecting the process include temperature, chemistry, and mobile phase composition.
- The analyses’ physiological properties, including size, charge, polarity, and volatility, are crucial in determining its effectiveness.
- The stationary phase's physiological properties, including polarity, charge, and viscosity, are crucial for understanding its behavior.
- The study explores the physiological properties of the mobile phase and its interaction with the analytic and stationary phases.
Growth Drivers
Advancements in pharmaceutical and biopharmaceutical fields.
The pharmaceutical and biopharmaceutical industries are expanding, necessitating the use of high-performance liquid chromatography (HPLC) systems for drug analysis, quality control, and research and development.
Green Chemistry Initiatives
Green HPLC techniques are being developed to reduce solvent usage and waste production, focusing on sustainability and environmental concerns.
Market Restraints
complexity and skill requirements of various tasks.
HPLC procedures are difficult to use and perhaps more expensive to operate since they need professional operators and specialized knowledge.
The competition from alternative technologies is gaining traction in various industries.
The HPLC market's growth may be hindered by the growing adoption of alternative analytical methods like capillary electrophoresis and mass spectrometry.
High Performance Liquid Chromatography (HPLC) Market Segment Analysis
High Performance Liquid Chromatography (HPLC) Market Analysis by Type
Normal-Phase HPLC
A non-polar solvent, such as hexane, and small silica particles are poured into the column. A typical column has a length of 150 to 250 mm, an internal diameter of 4.6 mm or less, and both. Because polar chemicals adhere to the polar silica for a longer period of time than non-polar compounds do, non-polar compounds in the mixture will move through the column more quickly.
Reversed-Phase HPLC
The column is filled with non-polar modified silica particles and long hydrocarbon chains, attached to the surface using a polar solvent like water and alcohol like methanol. This allows polar compounds to travel through the column more quickly due to the high attraction between the solvent and the polar molecules in the mixture.
High Performance Liquid Chromatography (HPLC) Market Analysis by Application
High Performance Liquid Chromatography (HPLC) is a crucial technique for early diagnosis of chronic illnesses by finding and measuring biomarkers. It improves diagnosis accuracy by highlighting similarities in similar illnesses. HPLC's consistency and low coefficient of variation make it ideal for metabolite analysis, particularly in vitamin D and HbA1c haemoglobin evaluations. The growing frequency of chronic illnesses and demand for reliable diagnostic methods are expected to drive significant growth in HPLC diagnostic applications.
High Performance Liquid Chromatography (HPLC) Market Analysis by End – User
In 2022, the pharmaceutical and biotechnology sectors dominated the market, accounting for over 38.56%. HPLC methods are widely used in these industries for quality control, drug purity, characterization, and ingredient stability assessment. The segment is expected to grow due to HPLC's compatibility with mass spectrometry, enhancing detection capabilities and selectivity. This potential holds significant promise for biopharmaceutical applications, driving market expansion.
Competitive Landscape of the High Performance Liquid Chromatography (HPLC) Market Analysis
New Developments in High Performance Liquid Chromatography (HPLC) Market
12 June 2023, Agilent Introduces New Comprehensive GPC/SEC Solutions at HPLC 2023 Conference
Agilent Technologies Inc. announced they will showcase their significantly expanded InfinityLab GPC/SEC Solution at the HPLC 2023 conference on June 18 – 22, 2023 in Düsseldorf, Germany.
The Agilent InfinityLab GPC/SEC portfolio has become even more comprehensive as it incorporates added value components from recent acquisition of Polymer Standard Service Ltd. (PSS) including a dedicated GPC/SEC Column Thermostat, a Multi-Angle Light Scattering Detector, the GPC/SEC-Ready Kit, and the powerful WinGPC Software into the already existing InfinityLab GPC/SEC Solutions for advanced material characterization.
In April 2022, Shimadzu unveiled LabSolutions MD software, which aids in the creation of analytical methods for high-performance liquid chromatography (HPLC). The program allows automated column and solvent screening and provides capabilities for established technique scouting.
In August 2021, an ultra-high performance liquid chromatography (UHPLC) and automated high performance liquid chromatography (HPLC) method development system was introduced by Thermo Fisher Scientific and ChromSword as a result of their collaboration. This system allows chromatographers to deliver robust and validated methods with greater assurance and in less time.
Regional Analysis
Largest Market-> North America
Fastest Growing Market-> Asia Pacific
North America is expected to dominate the market in the future due to the increasing use of advanced techniques and systems in High-Performance Liquid Chromatography (HPLC) production and technical developments in chromatographic studies. This growth is attributed to increased knowledge among research staff about the availability of cutting-edge chromatography studies in the industry, which is used by federal research organizations to examine ingredients in medication combinations.
Asia Pacific is expected to experience the fastest revenue growth rate globally, driven by increased investment in biotechnology and pharmaceutical research, as well as an increase in demand for biosimilars and generic drugs, compared to other global markets.
Europe ranked second in the global market in 2020, with drug discovery and pharmaceutical company growth expected to drive market development in the coming years.
Segments Covered in the High Performance Liquid Chromatography (HPLC) Market Report
High Performance Liquid Chromatography (HPLC) Market Analysis by Product
- Instruments
- HPLC Systems
- Pumps
- Detectors
- Others
- Consumables& Accessories
- Columns
- Reverse-phase HPLC Columns
- Normal-phase HPLC Columns
- Ion Exchange HPLC Columns
- Size Exclusion HPLC Columns
- Other HPLC Columns
- Filters
- Vials
- Tubes
- Others
- Software
High Performance Liquid Chromatography (HPLC) Market Analysis by Application
- Clinical Research Applications
- Diagnostic Applications
- Forensic Applications
- Other Applications
High Performance Liquid Chromatography (HPLC) Market Analysis by End - User
- Pharmaceutical & Biotechnology Companies
- Academic & Research Institutions
- Others
The above information has been provided for the following regions and countries:
North America
Europe
- UK
- Germany
- France
- Italy
- Russia
Asia Pacific
- China
- India
- Japan
- South Korea
Latin America
MEA
- UAE
- Saudi Arabia
- South Africa
Frequently Asked Questions
What is the expected growth rate of the High Performance Liquid Chromatography (HPLC) market over the next 7 years?
High Performance Liquid Chromatography (HPLC) Market is estimated to increase at a CAGR of 5.34% from $ 4.77 Billion in 2023 to $ 7.50 billion by 2030.
Who are the major players in the High Performance Liquid Chromatography (HPLC) market and what is their market share?
Agilent Technologies, Inc. (USA),Thermo Fisher Scientific, Inc. (USA),Shimadzu Corporation (Japan),Waters Corporation (USA),PerkinElmer, Inc. (USA),Bruker Corporation (USA),Bio-Rad Laboratories, Inc. (USA),JASCO Corporation (Japan),Gilson, Inc. (USA),Knauer GmbH (Germany), are prominent players operating and dominating in the market.
What is the demand projection for High Performance Liquid Chromatography (HPLC) by 2030?
Demand for High Performance Liquid Chromatography (HPLC) is projected to reach a market value of US$ 7.50 billion by 2030-end.
What is the sales growth projection for High Performance Liquid Chromatography (HPLC)?
Revenue from sales of High Performance Liquid Chromatography (HPLC) is projected to increase at a CAGR of 5.34% through 2030.
1.SUMMARY
1.1. High Performance Liquid Chromatography (HPLC) Market Overview
1.2. Key Insights
1.3. Report Scope
1.4. Research Methodology
1.5. Frequently Asked Questions
1.6. Chapter Outlines
- DECISION-MAKING SUMMARY
- INTRODUCTION
3.1. Overview of High Performance Liquid Chromatography (HPLC)
3.2. Key Historical Events
3.3. Structure
3.4. Biochemical Interaction
3.5. Target Indications
3.6. Advantages of High Performance Liquid Chromatography (HPLC)
3.7 Challenges associated with High Performance Liquid Chromatography (HPLC)
3.8. Future Perspectives.
- MARKET LANDSCAPE
4.1. Methodology
4.2 High Performance Liquid Chromatography (HPLC): Developer Landscape
4.2.1. Analysis by Year of Establishment
4.2.2. Analysis by Company Size
4.2.3. Analysis by Location of Headquarters (Region-wise)
4.2.4. Analysis by Location of Headquarters (Country-wise)
4.2.5. Analysis by Year of Establishment, Company Size and Location of Headquarters (Region-wise)
4.2.6. Most Active Players
- COMPANY
5.1. Company Overview
5.1.2 Management Team
5.1.3. Product Portfolio
5.1.4. Recent Developments and Future Outlook
- PARTNERSHIPS AND COLLABORATIONS
6.1. Partnership Models
6.2. High Performance Liquid Chromatography (HPLC): Partnerships and Collaborations
6.2.1. Analysis by Year of Partnership
6.2.2. Analysis by Type of Partnership
6.2.3. Analysis by Year and Type of Partnership
6.2.4. Analysis by Type of Partner
6.2.5. Analysis by Year of Partnership and Type of Partner
6.2.6. Analysis by Type of Partnership and Type of Partner
6.2.7. Analysis by Type of Partner and Parent Company Size
- ACADEMIC GRANTS ANALYSIS
7.1. Methodology and Key Parameters
7.2. High Performance Liquid Chromatography (HPLC): Academic Grants Analysis
7.2.1. Analysis by Year of Grant Award
7.2.2. Analysis by Amount Awarded
7.2.3. Analysis by Funding Institute Center
7.2.4. Analysis by Support Period
7.2.5. Analysis by Funding Institute Center and Support Period
7.2.6. Analysis by Type of Grant Application
7.2.7. Analysis by Purpose of Grant
- PUBLICATION ANALYSIS
8.1. Analysis Methodology and Key Parameters
8.2. High Performance Liquid Chromatography (HPLC): Publication Analysis
8.2.1. Analysis by Year of Publication
8.2.2. Analysis by Type of Publication
8.2.3. Analysis by Type of Conjugate
8.2.4. Analysis by Target Indication
8.2.5. Analysis by Copyright Holder
8.2.6. Word Cloud: Emerging Focus Area
8.2.7. Most Active Publishers: Analysis by Number of Publications
- SUCCESS PROTOCOL ANALYSIS
9.1. Methodology and Key Parameters
9.2. Key Assumptions and Scoring Criteria
9.3. Success Protocol Analysis
9.4. Assessment of Approved High Performance Liquid Chromatography (HPLC)
- Appendix 1: Tabulated Data
- Appendix 2: List of Companies
- Agilent Technologies, Inc. (USA)
- Thermo Fisher Scientific, Inc. (USA)
- Shimadzu Corporation (Japan)
- Waters Corporation (USA)
- PerkinElmer, Inc. (USA)
- Bruker Corporation (USA)
- Bio-Rad Laboratories, Inc. (USA)
- JASCO Corporation (Japan)
- Gilson, Inc. (USA)
- Knauer GmbH (Germany)
