High Performance Liquid Chromatography (HPLC) Market Snapshot

“The High Performance Liquid Chromatography (HPLC) Market is estimated to increase at a CAGR of 5.34% from $ 4.77 Billion in 2023 to $ 7.50 billion by 2030.”

High Performance Liquid Chromatography (HPLC) is the primary analytical method used in laboratories worldwide for separating, recognizing, and quantifying mixture components.

How Does High Performance Liquid Chromatography (HPLC) Work?

Column chromatography involves a solvent flowing through a column filled with an adsorbent-filled material, typically a granular substance like silica or polymers, under intense pressures of up to 400 atmospheres. HPLC has significantly improved this process, allowing for more accurate and efficient analysis.

Column chromatography is faster due to pressure, allowing for smaller particles in the column packing material. This allows for better separation of mixture components. The stationary phase interacts with molecules over a larger surface area in smaller particles, while the mobile phase, typically a combination of solvents like water, acetonitrile, and/or methanol, is pressurized.

The interaction between mixture components and absorbent particles determines their distance, resulting in varying elution rates and component separation. HPLC is highly sensitive and automated, unlike column chromatography, which is influenced by the interaction between components.

Every High Performance Liquid Chromatography (HPLC) analysis includes the following steps:

• Mobile phase begins to flow.
• Sample injection
• Compound separation
• Analyte detection
• Chromatogram generation.

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Factors affecting High Performance Liquid Chromatography (HPLC) separations

HPLC separations are influenced by temperature, stationary phase chemistry, and mobile phase composition. The right stationary phase is crucial for successful separation, as analytes have different affinity for the stationary phase. Primary variables affecting the process include temperature, chemistry, and mobile phase composition.

• The analyses’ physiological properties, including size, charge, polarity, and volatility, are crucial in determining its effectiveness.
• The stationary phase's physiological properties, including polarity, charge, and viscosity, are crucial for understanding its behavior.
• The study explores the physiological properties of the mobile phase and its interaction with the analytic and stationary phases.

Growth Drivers

Advancements in pharmaceutical and biopharmaceutical fields.

The pharmaceutical and biopharmaceutical industries are expanding, necessitating the use of high-performance liquid chromatography (HPLC) systems for drug analysis, quality control, and research and development.

Green Chemistry Initiatives

Green HPLC techniques are being developed to reduce solvent usage and waste production, focusing on sustainability and environmental concerns.

Market Restraints

complexity and skill requirements of various tasks.

HPLC procedures are difficult to use and perhaps more expensive to operate since they need professional operators and specialized knowledge.

The competition from alternative technologies is gaining traction in various industries.

The HPLC market's growth may be hindered by the growing adoption of alternative analytical methods like capillary electrophoresis and mass spectrometry.

High Performance Liquid Chromatography (HPLC) Market Segment Analysis

High Performance Liquid Chromatography (HPLC) Market Analysis by Type

Normal-Phase HPLC

A non-polar solvent, such as hexane, and small silica particles are poured into the column. A typical column has a length of 150 to 250 mm, an internal diameter of 4.6 mm or less, and both. Because polar chemicals adhere to the polar silica for a longer period of time than non-polar compounds do, non-polar compounds in the mixture will move through the column more quickly.

Reversed-Phase HPLC

The column is filled with non-polar modified silica particles and long hydrocarbon chains, attached to the surface using a polar solvent like water and alcohol like methanol. This allows polar compounds to travel through the column more quickly due to the high attraction between the solvent and the polar molecules in the mixture.

High Performance Liquid Chromatography (HPLC) Market Analysis by Application

High Performance Liquid Chromatography (HPLC) is a crucial technique for early diagnosis of chronic illnesses by finding and measuring biomarkers. It improves diagnosis accuracy by highlighting similarities in similar illnesses. HPLC's consistency and low coefficient of variation make it ideal for metabolite analysis, particularly in vitamin D and HbA1c haemoglobin evaluations. The growing frequency of chronic illnesses and demand for reliable diagnostic methods are expected to drive significant growth in HPLC diagnostic applications.

High Performance Liquid Chromatography (HPLC) Market Analysis by End – User

In 2022, the pharmaceutical and biotechnology sectors dominated the market, accounting for over 38.56%. HPLC methods are widely used in these industries for quality control, drug purity, characterization, and ingredient stability assessment. The segment is expected to grow due to HPLC's compatibility with mass spectrometry, enhancing detection capabilities and selectivity. This potential holds significant promise for biopharmaceutical applications, driving market expansion.

Competitive Landscape of the High Performance Liquid Chromatography (HPLC) Market Analysis

• Agilent Technologies, Inc. (USA)
• Thermo Fisher Scientific, Inc. (USA)
• Shimadzu Corporation (Japan)
• Waters Corporation (USA)
• PerkinElmer, Inc. (USA)
• Bruker Corporation (USA)
• Bio-Rad Laboratories, Inc. (USA)
• JASCO Corporation (Japan)
• Gilson, Inc. (USA)
• Knauer GmbH (Germany)

New Developments in High Performance Liquid Chromatography (HPLC) Market

12 June 2023, Agilent Introduces New Comprehensive GPC/SEC Solutions at HPLC 2023 Conference

Agilent Technologies Inc. announced they will showcase their significantly expanded InfinityLab GPC/SEC Solution at the HPLC 2023 conference on June 18 – 22, 2023 in Düsseldorf, Germany.

The Agilent InfinityLab GPC/SEC portfolio has become even more comprehensive as it incorporates added value components from recent acquisition of Polymer Standard Service Ltd. (PSS) including a dedicated GPC/SEC Column Thermostat, a Multi-Angle Light Scattering Detector, the GPC/SEC-Ready Kit, and the powerful WinGPC Software into the already existing InfinityLab GPC/SEC Solutions for advanced material characterization.

In April 2022, Shimadzu unveiled LabSolutions MD software, which aids in the creation of analytical methods for high-performance liquid chromatography (HPLC). The program allows automated column and solvent screening and provides capabilities for established technique scouting.

In August 2021, an ultra-high performance liquid chromatography (UHPLC) and automated high performance liquid chromatography (HPLC) method development system was introduced by Thermo Fisher Scientific and ChromSword as a result of their collaboration. This system allows chromatographers to deliver robust and validated methods with greater assurance and in less time.

Regional Analysis

Largest Market-> North America

Fastest Growing Market-> Asia Pacific

North America is expected to dominate the market in the future due to the increasing use of advanced techniques and systems in High-Performance Liquid Chromatography (HPLC) production and technical developments in chromatographic studies. This growth is attributed to increased knowledge among research staff about the availability of cutting-edge chromatography studies in the industry, which is used by federal research organizations to examine ingredients in medication combinations.

Asia Pacific is expected to experience the fastest revenue growth rate globally, driven by increased investment in biotechnology and pharmaceutical research, as well as an increase in demand for biosimilars and generic drugs, compared to other global markets.

Europe ranked second in the global market in 2020, with drug discovery and pharmaceutical company growth expected to drive market development in the coming years.

Segments Covered in the High Performance Liquid Chromatography (HPLC) Market Report

High Performance Liquid Chromatography (HPLC) Market Analysis by Product

• Instruments
• HPLC Systems
• Pumps
• Detectors
• Others
• Consumables& Accessories
• Columns
• Reverse-phase HPLC Columns
• Normal-phase HPLC Columns
• Ion Exchange HPLC Columns
• Size Exclusion HPLC Columns
• Other HPLC Columns
• Filters
• Vials
• Tubes
• Others
• Software

High Performance Liquid Chromatography (HPLC) Market Analysis by Application

• Clinical Research Applications
• Diagnostic Applications
• Forensic Applications
• Other Applications

High Performance Liquid Chromatography (HPLC) Market Analysis by End - User

• Pharmaceutical & Biotechnology Companies
• Academic & Research Institutions
• Others

The above information has been provided for the following regions and countries:

North America

• U.S.
• Canada

Europe

• UK
• Germany
• France
• Italy
• Russia

Asia Pacific

• China
• India
• Japan
• South Korea

Latin America

• Brazil
• Mexico

MEA

• UAE
• Saudi Arabia
• South Africa

Frequently Asked Questions

What is the expected growth rate of the High Performance Liquid Chromatography (HPLC) market over the next 7 years?

High Performance Liquid Chromatography (HPLC) Market is estimated to increase at a CAGR of 5.34% from $ 4.77 Billion in 2023 to $ 7.50 billion by 2030.

Who are the major players in the High Performance Liquid Chromatography (HPLC) market and what is their market share?

Agilent Technologies, Inc. (USA),Thermo Fisher Scientific, Inc. (USA),Shimadzu Corporation (Japan),Waters Corporation (USA),PerkinElmer, Inc. (USA),Bruker Corporation (USA),Bio-Rad Laboratories, Inc. (USA),JASCO Corporation (Japan),Gilson, Inc. (USA),Knauer GmbH (Germany), are prominent players operating and dominating in the market.

What is the demand projection for High Performance Liquid Chromatography (HPLC) by 2030?

Demand for High Performance Liquid Chromatography (HPLC) is projected to reach a market value of US$ 7.50 billion by 2030-end.

What is the sales growth projection for High Performance Liquid Chromatography (HPLC)?

Revenue from sales of High Performance Liquid Chromatography (HPLC) is projected to increase at a CAGR of 5.34% through 2030.